What is Vivitrol?



Searching for what is Vivitrol ? Vivitrol is the first and only non-addictive, once-monthly medication that, when combined with counseling, is proven to help prevent relapse to opioid dependence, after detox. Vivitrol is an antagonist or blocking medication. Antagonists attach to opioid receptors but do not cause the release of dopamine. As a result, they block the receptors from activating even if opiates are used. They are non-addictive and do not lead to physical dependence, which differentiates Vivitrol from other maintenance drugs such as Suboxone or Methadone. Vivitrol blocks opioid receptors in the brain for one month at a time, helping patients to prevent relapse to opioid dependence, following detox, while they focus on their road to recovery.

At Landmark, we encourage Opiate users to take Vivitrol post-discharge, as we believe Vivitrol significantly reduces the chance of relapse, and while Suboxone and Methadone can replace one addiction with another, Vivitrol is non-addictive, allowing the patient to live a life that is truly substance free. We even set patients up for their first Vivitrol appointment and ensure follow up during our regularly scheduled Alumni calls.

Once you’ve decided to make the decision to live a life free from drugs and alcohol, you may want to consider asking a clinical professional about medication assisted therapy as a part of your treatment. Some of the most common medications you may read about are Suboxone, Vivitrol, Antabuse, Methadone, and Campral. Though these medications can’t get you clean on their own. What these drugs do is help to curb cravings and lessen the negative side effects of withdrawal symptoms that make recovery so difficult. It’s important to find a medication that will adequately serve your needs while reducing the possibility for abuse.


What is Vivitrol?

The opioid crisis claimed the lives of more than 20,000 Americans in 2016. The drug Vivitrol was developed in order to address this growing problem concerning deaths from opioid overdose and abuse. Vivitrol is a drug that helps those recovering from addiction prevent relapse. It is an extended release, injectable form of naloxone, which acts as an opiate antagonist. What this means is that it essentially blocks the effects of opioids on the brain. It was initially approved by the FDA in 2010 for treating addiction. Vivitrol was the first non-narcotic, non-addictive, extended release medication approved for this kind of treatment.








This is an “agonist” drug that binds to the body’s opioid receptors and activates these receptors in the same manner that an opioid might. It is offered at many certified treatment facilities, and is usually administered in liquid form for daily use. Methadone has been used for decades to treat people who are addicted to heroin and narcotic pain medicines. When taken as prescribed, it allows people to recover from their addiction and to reclaim active and meaningful lives.



Suboxone is a combination of two different drugs: buprenorphine (an opioid activator) and naloxone (an opioid antagonist). This combination of opposing forces provides a way for addicts to gradually wean themselves off of their pre-existing addiction while minimizing the effects that full on withdrawal would otherwise trigger. Suboxone is administered with a light film or pill and is indicated for treatment of opioid dependence and should be used as part of a complete treatment plan to include counseling and psycho-social support.



Vivitrol is an “antagonist” that binds to opioid receptors, but only blocks them, stopping the effect of other opioid drugs. It can be prescribed by any health care provider and is taken as either a daily pill or a monthly injection. If you have used opioids or opioid-containing medicines prior to taking Vivitrol, using opioids in amounts that you used before treatment could potentially lead to overdose and death.




Vivitrol, like all forms of naltrexone, works by blocking the opioid receptors within the brain. The medicine binds to these receptors like glue and remains on them, ensuring that no high is attainable from taking another opioid. This is in contrast to medications such as methadone and buprenorphine which enact a mild euphoria from using. The drug is administered in only one dose, 380 mg, and must be administered by a clinical professional. The shot is taken once a month, and acts on extended release over that period, continually delivering medication.

Prior to taking the drug, the patient must be opioid free for a minimum of 7-10 days. The concentrations slowly decline a couple weeks after injecting. The drug is used for alcohol and opioid dependence. However it can be dangerous when patients are given Vivitrol but still attempt to get high on opioids or consume alcohol. This is because the blocking effect may lead to the patient over indulging in order to attain a high, which will only lead to serious injury or death.

However, unlike methadone, Vivitrol is not a controlled substance, meaning it can’t be abused and there is no black market for it. It wasn’t until researchers created an injectable, long-acting version that clinical studies showed the drug’s promise. Vivitrol has been tested in a six-month double blind study, where people who used Vivitrol with counseling to treat alcoholism had a greater reduction in the number of relapses, and more time spent abstinent from alcohol.




Teenage boy sleeping after searching what is viivtrol and attending a treatment center.

Many of the side effects that can occur from taking Vivitrol, and it isn’t the right drug for everyone. There significant risks associated with taking Vivitrol, such as risking a future overdose, or have a severe allergic reaction to the shot. There are also a range of more minor, but still negative side effects to be aware of. These include but are not limited to:

  • nausea
  • headache
  • dizziness
  • anxiety
  • nervousness
  • restlessness
  • irritability
  • tiredness
  • loss of appetite
  • increased thirst
  • muscle or joint aches
  • weakness
  • sleep problems (insomnia)
  • decreased sex drive
  • impotence
  • difficulty having an orgasm


On average, 44 people in the United States die every day from an overdose on opioid painkillers prescribed by a doctor or illicitly diverted from medical purposes. These drugs include Mophine, Codeine, Vicodin, and Percocet, and they inhibit the mind’s sensations of pain by binding to opioid receptors in the body. With prolonged usage, anyone can develop a strong dependency on these drugs, making the possibility of undergoing withdrawal symptoms more likely when the drug stops being taken.




As with any recovery treatment medication, many scientists and psychiatrists caution against labeling Vivitrol as a magic bullet or overstating its efficacy. It’s not the sole factor that can decide the outcome of treatment. However, taking the shot monthly can be extremely helpful for those facing daily cravings for opioids or alcohol. In one study conducted over 6-months, patients were given monthly injections of Vivitrol along with counseling against a different group taking a placebo with counseling. Patients were given drug tests to ensure they were not mixing substances. Though many participants did drop out of treatment, 36% of those in the Vivitrol group succeeded in total abstinence from opioids, compared with 23% in those treated with a placebo injection.




Vivitrol can help, but is not the sole solution. It takes enrolling in an accredited rehabilitation facility, with rehabilitation programs that combine counseling, psycho-therapeutic work and medication in order to help a person move forward in their recovery process.